What is Restylane®?Restylane is a safe and natural cosmetic dermal filler that restores volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as nasolabial folds.

What is Restylane made of?
Restylane is the fi rst cosmetic dermal filler made of non-animal-based hyaluronic acid.
Hyaluronic acid is a natural substance that already exists in the human body and is used to provide volume and fullness to the skin. The hyaluronic acid in Restylane is a crystal-clear gel called NASHA,™ or Non-Animal Stabilized Hyaluronic Acid. NASHA is biodegradable and fully biocompatible with human hyaluronic acid.

How is Restylane different than other hyaluronic acid-based products?
Unlike rooster-derived hyaluronic acidbased products, Restylane is free from animal
proteins. This quality limits any risk of animal-based disease transmission or allergic reaction. Restylane contains trace amounts of gram-positive bacterial proteins and should not be used by patients with a history of allergies to such material. Additionally, Restylane has the highest concentration of hyaluronic acid available in a dermal filler.

Is Restylane safe?
Yes. Restylane has been used by dermatologists and plastic surgeons since 1996 worldwide. There is limited risk of animalbased disease transmission or allergic reaction. Restylane is fully biocompatible and allergy testing is not required. Restylane contains trace amounts of gram-positive bacterial proteins and should not be used by patients with a history of allergies to such material. After your treatment, you might have some redness or swelling. This will normally last less than seven days. Sunbathing and cold outdoor activities should be avoided until any redness or swelling disappear. If you are pregnant, breastfeeding, or under 18, you shouldn’t use Restylane.

Where can products in the Restylane family be used?
The Restylane family of products includes Restylane, Restylane-L®, Perlane®, and Perlane-L®. These products can be used individually to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds or laugh lines); lipstick lines (the area just below the nose and above the upper lip); the corners of the mouth; and marionette lines (the area that extends downward from the corners of the mouth to the jawline).

The safety and effectiveness of products in the Restylane family for the treatment of anatomic regions other than nasolabial folds have not been established in controlled clinical studies. Patients should be limited to 6.0 mL per treatment.

How long does Restylane last?
Restylane is proven to deliver long-lasting results. Studies have shown that Restylane effects generally last for about six months1. Restylane’s stabilization technology helps maintain the cosmetic effect until the injected material is nearly gone.

How often should I have Restylane treatments done?
Treatments are typically scheduled twice a year. Having a touch-up treatment before the product has fully dissipated may enhance the lasting effect.

What should patients do prior to treatment?
Restylane requires no pretesting, but you should take a few precautions before being treated. Avoid using aspirin, non-steroidal anti-infl ammatory medications, St. John’s Wort, or high doses of Vitamin E supplements prior to treatment, because these may increase bruising or bleeding at the injection site. Also, if you have previously suffered from facial cold sores, discuss this with your physician. He/She may consider prescribing a medication to minimize recurrence.

How is Restylane different from Botox® Cosmetic?
Restylane is a natural, cosmetic fi ller. In contrast, Botox Cosmetic is a drug that blocks nerve transmission and relaxes the underlying muscles. Many patients have been very pleased after receiving treatment with both products.

How is Restylane different from bovine collagen?
Bovine collagen is derived from animals (cows) and requires an allergy test. Restylane can be administered immediately—no waiting is required.

Do the injections hurt?
Restylane® is injected directly into the skin in tiny amounts by an ultrafi ne needle, resulting in minimal discomfort. The procedure is simple and convenient, and results are practically instantaneous. To optimize your comfort during the short procedure, your physician may anesthetize the treatment area.

How much do Restylane treatments cost?
Restylane is a customized procedure based on your specifi c needs, so the cost will vary from patient to patient. In general, the cost of Restylane is comparable to the cost of
similar procedures. Because Restylane is long lasting, it proves to be very economical over the long term. Please consult your physician to determine the best recommendation for your particular needs.

Who is Medicis Aesthetics™?
Medicis Aesthetics is a subsidiary of Medicis,® a well-established dermatology company dedicated to helping patients attain a healthy and youthful appearance and self-image.

Safety information
After your treatment, you might have some redness or swelling. This will normally last less than seven days. Sunbathing and cold outdoor activities should be avoided until any redness or swelling disappear. If you are pregnant, breastfeeding, or under 18, you shouldn’t use Restylane. For complete product and safety information, visit www.RestylaneUSA.com